Chronic constipation is a common gastrointestinal disorder that affects physical and social functioning and significantly interferes with daily living and wellbeing. Therapies for constipation typically include lifestyle and dietary modifications in combination with pharmacological therapeutics. Patients with constipation, however, are often not completely satisfied with their treatments due to efficacy and safety concerns. With Chinese Medicine has been used for the management of constipation for a long time. We have tested the efficacy of MZRW granule for constipation in serial clinical trials and found it is better than the existing first-line drug. Our multidisciplinary team aims to develop CDD-2101, as a botanical drug for constipation related conditions and the advanced version CDD-2105 as a botanical drug for visceral pain and constipation related conditions based on the requirements of the U. S. FDA. Further, the mechanism of clinical efficacy will be extensively investigated.